Research on the application value of amplitude-integrated electroencephalography in the diagnosis and prognosis of brain injury in preterm infants exposed to perinatal infections
LU Tian-tian
FENG Yong-hong
ZHANG Li
LIN Qun
YANG Xiao-gui
CHEN Xiu-ling
CAI Jiang-yun
Abstract：Objective To investigate the application value of amplitude-integrated electroencephalography(aEEG)in the diagnosis and prognosis of brain injury in preterm infants exposed to perinatal infections.And to provide clinical reference.Methods From June 2022 to June 2023,136 preterm infants,born before 32 weeks of gestation and exposed to perinatal infections were selected and included.The infants were divided into two groups:the brain injury group(36 cases)and the non-braininjury group(100 cases).ClinicaldataandaEEGresultswerecollectedandcom-pared between the two groups.Risk factors for brain injury were analyzed,and a predictive model for brain injury risk was constructed.The discriminative ability and calibration of the predictive model were assessed using the area under the re-ceiver operation characteristics(ROC)curve(AUC)and calibration curve.Results Factor analysis indicated that intra-uterine infection,spontaneous delivery,aEEG pattern continuity,sleep-wake cycle,spectral bandwidth,and lower boundary amplitude variation were independent risk factors for brain injury in preterm infants exposed to perinatal infec-tions.The predictive model showed good predictive value for brain injury risk,with an AUC of 0.824(95%CI:0.753-0.895),a maximum Youden index of 0.522,sensitivity of 0.731,and specificity of 0.791.The Hosmer-Lemeshow goodness-of-fit test indicated that the predicted probabilities were consistent with the actual outcomes(P>0.05).In-fants with lower scores for aEEG pattern continuity,sleep-wake cycle,and spectral width and amplitude variation had poo-rer prognosis,with a significant negative correlation with long-term neurological outcomes(P<0.05).Conclusion aEEG monitoring has significant application value in the early diagnosis of brain injury in preterm infants exposed to peri-natal infections and can predict long-term neurological development outcomes.
Keywords：amplitude integrated electroencephalogramperinatal infectionpremature infantsbrain injuryap-plication value
Publication Date：2025-03-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 413-418 )