Value of atypical cell detection via urinary sediment analyzer in bladder cancer screening
XU Qiao-ping
YU Lin-tao
CHEN Juan
WU Zhi-cheng
Abstract：Objective To evaluate the value of detecting the atypical cells(Atyp.C)using an automated urine sediment analyzer for bladder cancer screening.Methods Using the SYSMEX UF-5000 automated urine sediment ana-lyzer,19 362 urine specimens from suspected urinary system disease cases were analyzed between September 2022 and March 2023.Among these,231 specimens tested positive for Atyp.C,while 100 Atyp.C-negative samples were random-ly selected for comparison.All samples underwent Wright staining and morphological classification.The diagnostic efficacy of Atyp.C for bladder cancer was evaluated using positive predictive value(PPV),negative predictive value(NPV),and receiver operating characteristic(ROC)curve analysis.Results Among the 231 Atyp.C-positive samples,84 showed abnormal cellular morphology,with 18 cases clinically diagnosed as bladder cancer.The positive predictive value for blad-der cancer diagnosis using the urinary sediment analyzer was 7.8％,while the negative predictive value was 100.0％,with a sensitivity of 100.0％,specificity of 31.9％,and overall concordance of 35.6％.The area under the ROC curve(AUC)was 0.647,with a sensitivity of 70.7％and specificity of 54.8％.Conclusion Atyp.C detection can serve as an adjunctive screening method for bladder cancer,enabling identification of high-risk patients who may require further follow-up or treatment.
Keywords：bladder cancerurinalysisatypical cellscytologyurine sediment analyzer
Publication Date：2025-02-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 278-283 )