Analysis of differences in pathological results between stereotactic brain biopsy and craniotomy resection
LI Min
TU Bin-feng
LUO Qing-feng
LI Dong-hai
LI Jian-bin
DENG Guo-jun
ZHONG Fang-ping
Abstract：Objective To evaluate the practical value of stereotactic brain biopsy in diagnosing intracranial le-sions,analyze the pathological differences between stereotactic brain biopsy and craniotomy resection,and explore ways to improve the diagnostic accuracy of stereotactic brain biopsy.Methods A retrospective analysis was conducted on 33 ca-ses from Jiangxi Cancer Hospital between September 2018 and October 2023,where patients underwent stereotactic brain biopsy followed by craniotomy resection.The pathological differences between the two procedures were compared to assess the practical value of stereotactic brain biopsy and identify areas for improvement.Results The average age of the 33 pa-tients was 53.1 years(range:25-80 years),including 20 males and 13 females.Conventional histopathology of ster-eotactic biopsy identified astrocytoma in 23 cases,malignant tumors in 4 cases,atypical cells in 1 case,gliosis in 3 cases,meningioma in 1 case,and ependymoma in 1 case.Craniotomy resection confirmed astrocytoma in 27 cases,metastatic cancer in 3 cases,meningioma in 1 case,spindle cell tumor in 1 case,and lymphoma in 1 case.Immunohistochemical re-sults from stereotactic biopsy revealed astrocytoma in 27 cases(Grade Ⅱ:15 cases;Grade Ⅲ:5 cases;Grade Ⅳ:7 ca-ses),metastatic cancer in 3 cases,ependymoma in 1 case,meningioma in 1 case,and diffuse large B-cell lymphoma in 1 case.Craniotomy resection confirmed astrocytoma in 28 cases(Grade Ⅱ:13 cases;Grade Ⅲ:6 cases;Grade Ⅳ:9 cases),metastatic cancer in 3 cases,meningioma in 1 case,and diffuse large B-cell lymphoma in 1 case.The overall discrepancy rate in conventional histopathology was 12.12％(4 cases),while differences in immunohistochemical diag-nostic classification and grading were 18.18％(6 cases).Differences in immunomarkers,especially Ki-67,were as high as 36.36％(12 cases).Conclusion Stereotactic brain biopsy is a reliable method for diagnosing intracranial le-sions.Although it may not fully capture the biological characteristics of the lesions,it meets clinical diagnostic needs.Im-proving imaging interpretation and puncture techniques can help obtain more representative results.
Keywords：brain stereotactic biopsycraniotomypathologydifference analysis
Publication Date：2025-02-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 261-266 )