Analysis of the correlation between intraoperative red blood cell transfusion and postoperative hospital-acquired infections in patients with Stanford type A aortic dissection
RUAN Zong-fa
LONG Qi-lin
LIANG Hong-kai
MAI Jie-he
ZHAO Zhan-yuan
Abstract：Objective To investigate the correlation between intraoperative red blood cell transfusion and the in-cidence of postoperative hospital-acquired infections in patients with Stanford type A aortic dissection.Methods A ret-rospective analysis was conducted on clinical data from patients with Stanford type A aortic dissection treated at Zhongshan People's Hospital from June 2018 to June 2023.A multivariate logistic regression analysis model was used to explore the relationship between intraoperative red blood cell transfusion and the occurrence of postoperative hospital infections.Re-sults Among the 250 included patients,162(64.8％)received intraoperative allogeneic red blood cell transfusions,while 88(35.2％)did not.The adjusted odds ratios for postoperative hospital-acquired infections were 2.38(95％CI:1.19-4.75)for patients receiving 1-3 units and 2.64(95％CI:1.43-4.87)for those receiving 4 or more units of allogeneic red blood cells.The restricted cubic spline model revealed an"inverse L"curve relationship between intraoper-ative red blood cell transfusion and the rate of postoperative infections,with a turning point at 6.25 units.For transfusions less than 6.25 units,the adjusted odds ratio for hospital-acquired infections was 1.197(95％CI:1.039-1.38).However,for transfusions of 6.25 units or more,there was no statistically significant association with postoperative infec-tions(P＞0.05).Conclusion In patients undergoing surgery for Stanford type A aortic dissection,intraoperative alloge-neic red blood cell transfusion is associated with an increased rate of postoperative infections.The relationship between the volume of red blood cell transfusion and the incidence of postoperative infections follows an"inverse L"shape;transfusion volumes less than 6.25 units correlate with a higher infection risk,while volumes of 6.25 units or more show no significant association with postoperative infections.
Keywords：Stanford type A aortic dissectionsurgical treatmentintraoperative transfusion of allogeneic red blood cellshospital acquired infection
Publication Date：2024-12-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1612-1616 )