Correlation between residual renal function and major adverse cardiovascular events in peritoneal dialysis patients

SHI Xin-hui; REN Dong-sheng; LU Bing; GU Yu; XU Guang

doi:10.13820/j.cnki.gdyx.20240816

Abstract：Objective To investigate the correlation between residual renal function and the occurrence of major adverse cardiovascular events(MACE)in peritoneal dialysis(PD)patients and to evaluate the predictive efficacy of re-sidual renal function and other clinical factors on MACE risk.Methods A total of 198 patients who underwent peritoneal dialysis from February 2021 to June 2023 were prospectively enrolled.Patients were divided into two groups based on the occurrence of MACE within six months:MACE group(n=42)and non-MACE group(n=156).Clinical data,inclu-ding residual renal function parameters,were collected through the hospital's electronic medical record system.Univariate and multivariate logistic regression analyses were performed to identify independent risk factors for MACE,and the receiver operating characteristic(ROC)curve was used to assess the predictive value of residual renal function and other clinical factors for MACE.Results Both univariate and multivariate logistic regression analyses indicated that serum urea nitro-gen,residual glomerular filtration rate(GFR),residual creatinine clearance rate(Ccr),residual Kt/V(urea clearance index),along with smoking history,duration of kidney disease,cardiac function classification,and hypertension were in-dependent predictors of MACE in PD patients(P＜0.05).ROC curve analysis demonstrated that individual and combined residual renal function parameters had good predictive efficacy for MACE occurrence.Conclusion Residual renal func-tion parameters in PD patients are generally reduced,with serum urea nitrogen,residual GFR,residual Ccr,and residual Kt/V levels closely related to MACE occurrence.These indicators,either individually or in combination,effectively pre-dict the risk of MACE in PD patients.