Efficacy analysis of wedge resection of the thyroid cartilage in patients with anteriorly invasive T1T2 glottic laryn-geal cancer
CHEN Wei-zhang
DAI De
Abstract：Objective To evaluate the efficacy of wedge resection of the thyroid cartilage in surgical management of anteriorly invasive T1T2 glottic laryngeal cancer.Methods This study included 60 patients diagnosed with T1T2 glot-tic laryngeal cancer,primarily exhibiting anterior invasion,subglottic extension,and infiltrative growth,treated at Meizhou People's Hospital from January 2015 to January 2021.Patients were randomly assigned to two groups:the obser-vation group(30 patients)underwent conventional laryngotomy,with cancer extent assessed,followed by wedge resection of the thyroid cartilage,ensuring complete tumor excision at a safe margin.Frozen section analysis of the margin showed no cancer before performing laryngeal function reconstruction.The control group(30 patients)received standard laryngot-omy and vocal cord cancer excision.Postoperative follow-up was conducted to compare and analyze voice quality,com-plication rates,extubation rates,recurrence rates,and survival rates between the two groups.Results At the end of the follow-up period,there was a statistically significant difference in recurrence rates between the two groups(6.7％vs.26.7％,P＜0.05).No significant differences were observed in extubation rates and survival rates(P＞0.05).The total complication rate was significantly different between the two groups(23.33％vs.53.33％P＜0.05).At six months postoperative,the Voice Handicap Index-10(VHI-10)score was significantly higher in the control group compared to the observation group(5.83±2.829 vs.24.33±4.936,P＜0.05).Conclusion The application of wedge resection of the thyroid cartilage in surgeries for anteriorly invasive,subglottic,and infiltrative T1T2 glottic laryngeal cancer is benefi-cial for restoring vocal function,associated with fewer complications and lower local recurrence rates.This technique re-presents a feasible and effective treatment option for early-stage glottic laryngeal cancer.
Keywords：T1T2 glottic laryngeal cancerwedge resection of thyroid cartilagelaryngotomyvoice handicap index
Publication Date：2024-11-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1439-1443 )