Study on the expression of biochemical indicators and their diagnostic value in malignant,borderline,and benign ovarian tumors
CUI Xin
XU Juan
JIA Xue-mei
Abstract：Objective Metabolic abnormalities are key markers of tumors;however,whether borderline ovarian tumors undergo metabolic changes is unclear.This study aims to explore the expression patterns and diagnostic value of se-rum biochemical indicators in malignant,borderline,and benign ovarian tumors,providing new evidence for the preopera-tive assessment of borderline ovarian tumors.Methods A retrospective analysis was conducted on the clinical data and preoperative serum biochemical indicators and tumor markers of 439 ovarian tumor patients,including 92 in the malignant group,74 in the borderline group,and 273 in the benign group.Pathological results were used as the"gold standard"to analyze the expression levels and diagnostic value of various indicators.Results Significant statistical differences were found in lactate dehydrogenase(LDH),alkaline phosphatase(ALP),homocysteine(Hcy),albumin,total protein,reti-nol-binding protein(RBP),sodium,and calcium,as well as HE4,CA125,CA153,and CA199 between malignant and borderline ovarian tumors.Significant differences were also noted in LDH,ALP,and tumor markers(HE4,CA125,CA199)between borderline and benign ovarian tumors.HE4 had the largest area under the ROC curve(AUC)when dis-tinguishing between malignant-borderline and malignant-benign tumors.CA125 showed the greatest diagnostic value in differentiating between borderline and benign tumors.LDH,albumin,and RBP were the most valuable biochemical indi-cators for diagnosing malignant-borderline ovarian tumors(AUC＞0.7).The combination of HE4 with ALP and albumin provided the highest diagnostic value in differentiating malignant from borderline tumors,while CA125 combined with HE4 and ALP had the highest value for borderline versus benign tumors(AUC=0.841).However,combining biochemical in-dicators did not enhance the AUC compared to using tumor markers alone.Conclusion There are significant differences in various biochemical indicators between malignant and borderline ovarian tumors,and LDH and ALP also show notable differences between borderline and benign tumors,suggesting metabolic changes in borderline ovarian tumors.However,combining biochemical and tumor indicators does not improve the diagnostic value for borderline ovarian tumors.
Keywords：borderline ovarian tumorsdifferential diagnosislactate dehydrogenasealkaline phosphatasereti-nol-binding proteinalbumin
Publication Date：2024-11-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 1418-1424 )