Factors influencing poor visual outcomes in patients with retinal vein occlusion after anti-vascular endothelial growth factor therapy

YANG Ting-ting; LIU Jia-yan; ZENG Feng; LU Ya-mei

doi:10.13820/j.cnki.gdyx.20241055

Abstract：Objective To evaluate the factors influencing poor visual outcomes in patients with retinal vein occlu-sion(RVO)after receiving anti-vascular endothelial growth factor(VEGF)therapy.Methods This study included patients diagnosed with RVO and treated with anti-VEGF therapy at Qingyuan Hospital affiliated with Guangzhou Medical University from June 2018 to June 2023.Clinical and ocular data were collected.Patients were divided into two groups based on their final best-corrected visual acuity(BCVA)in logMAR:a poor vision group(final logMAR BCVA＞1)and a control group(final logMAR BCVA≤1).Characteristics of the two groups were compared,and risk factors for poor visual outcomes were analyzed.Results Among 177 patients meeting the inclusion criteria,70 were in the poor vision group and 107 were in the control group.The poor vision group had significantly higher rates of older age,central RVO,inner retinal layer disorganization,and external limiting membrane disruption(P＜0.05).Baseline vision and hematocrit were significantly lower in the poor vision group(P＜0.05).Multivariate logistic regression analysis showed that carotid artery disease(OR=3.40,95％CI:1.22-12.44;P＜0.05),baseline vision(OR=0.01,95％CI:0.00-0.005;P＜0.001),inner retinal layer disorganization(OR=7.80,95％CI:2.33-26.15;P＜0.05),external limiting mem-brane disruption(OR=6.87,95％CI:2.05-23.00;P＜0.05),and hematocrit(OR=1 415 526,95％CI:21.69-9.24x1010;P＜0.05)were significantly associated with poor visual outcomes after anti-VEGF therapy in RVO pa-tients.Conclusion Carotid artery disease,poor baseline vision,inner retinal layer disorganization,external limiting membrane disruption,and lower hematocrit are risk factors for poor visual outcomes in RVO patients after anti-VEGF therapy.