Prognostic factors for patients with primary central nervous system diffuse large B-cell lymphoma:an analysis based on the SEER database
LI Zhuo-ran
XU Zhi-xiu
LI Qing
MAO Xiao-na
Abstract：Objective To investigate the prognostic factors affecting patients with primary central nervous system diffuse large B-cell lymphoma(PCNS-DLBCL).Methods Data were extracted from the Surveillance,Epidemiolo-gy,and End Results(SEER)database,selecting patients diagnosed with PCNS-DLBCL from 17 research centers be-tween 2000 and 2020.The log-rank test and Cox regression model were used to identify independent prognostic factors influencing overall survival(OS)in these patients.Results A total of 3 550 patients were included in the study.Log-rank test analysis revealed statistically significant differences in OS among patients in different age groups,with different affected sites,surgical approaches,whether they received radiotherapy,chemotherapy,combined chemoradiotherapy,or a combination of surgery,chemotherapy,and radiotherapy(P＜0.001,P＜0.001,P＜0.001,P＜0.001,P＜0.001,P=0.001,P＜0.001,P＜0.001).Cox multivariate regression analysis indicated that patients aged 60-69 and those 70 had significantly different OS compared to patients＜60 years old(HR=1.600,95％CI:1.447-1.769,P＜0.001;HR=2.317,95％CI:2.110-2.544,P＜0.001).Patients with multiple lesion involvement had a significantly different OS compared to those with supratentorial lesions(HR=1.227,95％CI:1.083-1.390,P=0.001).Partial tumor resection and complete tumor resection were significant protective factors for OS compared to no surgery(HR=0.794,95％CI:0.731-0.862,P＜0.001;HR=0.829,95％CI:0.716-0.959,P=0.012).Chemotherapy was also a significant protective factor for OS compared to no chemotherapy(HR=0.455,95％CI:0.417-0.496,P＜0.001).Conclusion Being ≥60 years old and having multiple lesion sites are independent risk factors for poor prognosis in pa-tients with PCNS-DLBCL,whereas chemotherapy,partial tumor resection,and complete tumor resection are independent protective factors for better prognosis in these patients.
Keywords：primary central nervous system lymphomadiffuse large B cellsoverall survivalprognostic factors
Publication Date：2024-10-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 1319-1325 )