Clinical significance of deubiquitinase OUTD3 expression in type Ⅱ endometrial cancer
WANG Peng-qiao
ZHANG San-yuan
Abstract：Objective To elucidate the role of ovarian tumor domain-containing protein-3(OTUD3)as a prognostic biomarker in endometrial cancer(EC)through immunohistochemical staining and statistical analysis.Methods The study involved 86 patients with type Ⅱ EC.Immunohistochemical staining for OTUD3 was performed,and the pa-tients were divided into low OTUD3 expression group(n=26)and high OTUD3 expression group(n=60)based on stai-ning intensity.The correlation between OTUD3 expression and other clinicopathological factors,as well as its prognostic impact,was analyzed using statistical methods.Results Immunohistochemical analysis of OTUD3 expression in type ⅡEC tissues indicated a significant positive correlation between high OTUD3 expression level and overall survival(OS)(HR=0.405,P=0.044),but high OTUD3 expression level was not acsociated with progression-free survival(PFS)(HR=0.513,P=0.079),based on univariate and multivariate Cox regression analyses.High OTUD3 expression was also associated with local recurrence in recurrent cases(P=0.041).Conclusion OTUD3 expression can predict survival and disease recurrence in patients with type Ⅱ EC.
Keywords：endometrial carcinomavarian tumor domain-containing protein-3progression-free survivaloverall survivalimmunohistochemistryCox regression analysis
Publication Date：2024-10-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1289-1293 )