Therapeutic effects and safety of transthoracic ultrasound-guided closure in patients with patent foramen ovale and coronary artery disease
FAN Shu-yu
YU Hui-juan
WANG Zheng-fei
Abstract：Objective To explore the treatment effects and safety of transthoracic ultrasound-guided closure combined with percutaneous coronary intervention(PCI)in patients with coronary artery disease and patent foramen ovale(PFO).Methods A retrospective analysis was conducted on the clinical data of 110 patients who underwent PFO closure combined with PCI from February 2021 to March 2024.Among them,50 patients underwent X-ray-guided PFO closure(X-ray group),and 60 patients underwent transthoracic echocardiography(TTE)-guided PFO closure(TTE group).The study compared perioperative cardiac function indices,shunt status,complication rates,and adverse events during follow-up,including bleeding,paradoxical embolism,myocardial infarction,sudden death,and stroke.Results There were no significant differences in closure time,PCI time,and hospital stay between the TTE and X-ray groups(P＞0.05).Post-treatment,cardiac function indices improved in both groups compared to pre-treatment(P＜0.05),with no significant differences between groups(P＞0.05).Shunt status also improved post-treatment(P＜0.05),but differences between groups were not statistically significant(P＞0.05).The complication and adverse event rates were similar between the two groups(P＞0.05).The Log-rank test indicated no significant difference in clinical event-free survival between TTE-guided and X-ray-guided PFO closure combined with PCI(HR=0.783,95％CI:0.324-1.895,P=0.582).Conclusion For patients with PFO and coronary artery disease,TTE-guided PFO closure combined with PCI is as safe and feasible as X-ray-guided methods.TTE procedures can help reduce radiation exposure in clinical settings while maintaining good safety.
Keywords：patent foramen ovalecoronary heart diseaseultrasound guidancepercutaneous coronary interven-tiontransthoracic closure surgery
Publication Date：2024-10-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1242-1246 )