Retrospective analysis of clinical characteristics and related factors in patients with heart failure with reduced ejection fraction HFrEF

ZHAO Jia; ZHANG Xiao-yun; RAN Dan

doi:10.13820/j.cnki.gdyx.20240475

Abstract：Objective To investigate and analyze the clinical characteristics of patients with heart failure with re-duced ejection fraction(HFrEF).Methods A total of 153 HFrEF patients admitted to the Department of Cardiology of Pengzhou People's Hospital and registered in the heart failure center database from May 2019 to June 2023 were included in this retrospective analysis.Clinical data were collected and analyzed for relevant factors.Results The proportion of male HFrEF patients was higher than that of females,and the average age of male patients was significantly lower(P=0.001).Males had higher left ventricular internal diameters and uric acid levels(P=0.001,P=0.038),both showing statistical significance(P＜0.05).The 45-75 age group had a larger left ventricle(P=0.027)compared to the group aged over 75.Regarding uric acid levels,patients under 45 had the highest levels,followed by those aged 45-75,with the lowest levels in the over-75 group(P＜0.05).In terms of etiology,patients with dilated cardiomyopathy were youn-ger than those with coronary artery disease(P=0.001).Additionally,patients with dilated cardiomyopathy had lower ejection fractions(EF)compared to those with coronary artery disease or hypertension.Patients with heart valve disease,coronary artery disease,hypertension,and arrhythmias had significantly different left ventricular(LV)values compared to those with dilated cardiomyopathy(P＜0.05).Patients in NYHA class Ⅱ were younger and had lower NT-proBNP lev-els than those in NYHA class Ⅲ or Ⅳ,with statistically significant differences(P＜0.05).No significant differences were observed in age,EF,LV,NT-proBNP,creatinine,uric acid,or LDL-C levels across HFrEF patients with differ-ent baseline heart rhythms.Pearson correlation analysis revealed a negative correlation between EF and LV(P=0.000,r=-0.425),and a negative correlation between age and uric acid levels(P=0.000,r=-0.398).Spearman analysis showed a positive correlation between NYHA class and NT-proBNP levels(P=0.000,r=0.393).Conclusion HFrEF patients exhibit distinct clinical characteristics depending on gender,etiology,and age group.There is a positive correla-tion between NYHA functional classification and NT-proBNP levels,suggesting that NT-proBNP can be used to assess heart function and disease severity in HFrEF patients.