Association between elevated HE4 levels and type 2 diabetes mellitus complicated by coronary heart disease
CHU Jin-shen
BO Chun-yan
XUE Guo-hui
WAN Fang
CAO Jun-da
CHEN Ke-qi
CHEN Jing
LIU Xiao-feng
CHEN Xue-li
Abstract：Objective To investigate the relationship between type 2 diabetes mellitus(T2DM)complicated by coronary heart disease(CHD)and serum levels of human epididymis protein 4(HE4).Methods A total of 116 T2DM patients treated in the hospital were selected as the observation group.Based on whether they had CHD,they were divided into a simple T2DM group(n=95)and a T2DM combined with CHD group(n=21).An additional 50 healthy individu-als,matched by gender and age,were selected as the control group.Serum HE4 levels were measured in all enrolled par-ticipants,along with inflammatory markers,liver and kidney function,blood lipids,routine blood tests,and coagulation function indicators.The changes in HE4 levels among the groups were analyzed,as well as the correlation between HE4 and various laboratory indicators.Logistic regression was used to analyze the influencing factors of T2DM complicated by CHD.Results Compared with the control group,HE4 levels in the observation group were significantly elevated[(110.0±70.5)pmol/L vs.(50.5±15.5)pmol/L],and the HE4 levels in the T2DM combined with CHD group[(178.2±88.0)pmol/L]were significantly higher than those in the T2DM group[(94.6±56.2)pmol/L](P=0.003).Spearman correlation analysis showed a significant positive correlation between HE4 and D-Dimer,Fibrinogen(FBG),C-Reactive Protein(CRP),and Homocysteine(HCY),while there was a significant negative correlation be-tween HE4 and Albumin(ALB),Prealbumin(PA),and Estimated Glomerular Filtration Rate(eGFR).Logistic regres-sion analysis across three models indicated that HE4 is an independent risk factor for T2DM complicated by CHD.The ar-ea under the curve(AUC)for distinguishing T2DM from T2DM combined with CHD was 0.786(95％CI:0.649-0.924),which was higher than that of eGFR(0.710,95％CI:0.593-0.827),CRP(0.720,95％CI:0.604-0.835),and HCY(0.758,95％CI:0.652-0.864).Conclusion Elevated HE4 levels are associated with T2DM complicated by CHD,providing new insights and potential targets for studying this condition.
Keywords：type 2 diabetes mellituscoronary heart diseasehuman epididymis protein 4
Publication Date：2024-10-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 1231-1236 )