Study on the correlations between serum sTWEAK,sLOX-1,and carotid atherosclerosis in patients with H-type hypertension complicated by HFpEF
JIANG Jin-zhong
GUO Hua
MIAO Wei
TIAN Shou-sen
TIAN Wen-yan
Abstract：Objective To investigate the relationship between serum soluble tumor necrosis factor-like weak in-ducer of apoptosis(sTWEAK),soluble lectin-like oxidized low-density lipoprotein receptor-1(sLOX-1),and ca-rotid atherosclerosis in patients with H-type hypertension complicated by heart failure with preserved ejection fraction(HFpEF).Methods A total of 161 patients with H-type hypertension and HFpEF admitted to Cangzhou Traditional Chinese and Western Medicine Hospital from February 2021 to March 2023 were selected.They were divided into athero-sclerosis and non-atherosclerosis groups based on the presence of carotid atherosclerosis.Additionally,80 healthy volun-teers undergoing routine health checks were selected as a control group.Clinical data were collected,and serum levels of sTWEAK and sLOX-1 were measured using enzyme-linked immunosorbent assay(ELISA).The serum levels of sTWEAK and sLOX-1 in patients with H-type hypertension and HFpEF were compared to those in the control group.Multivariate logistic regression analysis was conducted to identify factors influencing carotid atherosclerosis,and receiver operating characteristic(ROC)curve analysis was performed to assess the predictive value of serum sTWEAK and sLOX-1 for carotid atherosclerosis.Results Among the 161 patients,65 were found to have carotid atherosclerosis,resulting in an incidence rate of 40.37％(65/161).Significant differences were observed between the two groups regarding age,smoking,and lipid levels(P＜0.05).Serum sTWEAK levels were lower in both atherosclerosis and non-atherosclerosis groups compared to the control group,while sLOX-1 levels were higher(P＜0.05).Additionally,sTWEAK levels were lower and sLOX-1 levels were higher in the atherosclerosis group compared to the non-atherosclerosis group(P＜0.05).Multivariate logistic regression analysis indicated that HDL-C,sTWEAK,age,LDL-C,and sLOX-1 levels were significant factors influencing the occurrence of carotid atherosclerosis(P＜0.05).The ROC curve analysis revealed that the combined detection of serum sTWEAK and sLOX-1 had an area under the curve(AUC)of 0.842 for predicting carotid atherosclerosis,demonstrating higher predictive efficacy than either marker alone.Conclusion Decreased serum sTWEAK levels and increased sLOX-1 levels in patients with H-type hypertension complicated by HFpEF are associat-ed with the occurrence of carotid atherosclerosis.The combined measurement of both biomarkers holds predictive value for the onset of carotid atherosclerosis.
Keywords：H-type hypertensionheart failure with preserved ejection fractioncarotid atherosclerosisserum soluble tumor necrosis factor-like weak inducer of apoptosissoluble lectin-like oxidized low-density lipoprotein receptor-1
Publication Date：2024-10-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1226-1230 )