Expression and clinical significance of lncRNA DLX6-AS1 in tissues and serum exosomes of cervical cancer pa-tients
LIN Li-hui
YAN Zhi-qiang
REN Qing
ZENG Si-heng
Abstract：Objective To investigate the expression levels and clinical significance of long non-coding RNA DLX6-AS1(lncRNA DLX6-AS1)in tissues and serum exosomes of cervical cancer patients.Methods Eighty-two cervical cancer patients admitted between April 2022 and April 2023 at the Department of Gynecology,Hainan West Cen-tral Hospital were included as the study group,and 82 women with uterine fibroids were selected as the control group.Cer-vical cancer tissues and serum exosomes were collected postoperatively from the patients.The expression levels of lncRNA DLX6-AS1 in tissue samples and serum exosomes were quantified using real-time quantitative PCR(qRT-PCR).The clinical diagnostic value of lncRNA DLX6-AS1 for cervical cancer was evaluated using receiver operating characteristic(ROC)curve analysis.Results The relative expression levels of lncRNA DLX6-AS1 in both cervical cancer tissues and serum exosomes were significantly higher in the study group compared to the control group(P＜0.05).Statistical differences in lncRNA DLX6-AS1 expression were observed in cervical cancer tissues and serum exosomes among pa-tients at different FIGO stages and with lymph node metastasis or not(P＜0.05).The area under the ROC curve(AUC)for diagnosing cervical cancer using lncRNA DLX6-AS1 alone in tissue,alone in serum exosomes,and in combination were 0.740,0.692,and 0.781,respectively.Conclusion Elevated expression levels of lncRNA DLX6-AS1 in both tissues and serum exosomes are associated with cervical cancer and its severity.lncRNA DLX6-AS1 may serve as a po-tential biomarker for the diagnosis and prognosis of cervical cancer.
Keywords：cervical cancerlong non-coding RNA DLX6-AS1exosomebiological marker
Publication Date：2024-09-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1149-1153 )