Efficacy of mirror neuron therapy in treating phase Ⅰ complex regional pain syndrome post-stroke and its effects on serum substance P and calcitonin gene-related peptide levels
SONG Yu-jin
ZHANG Wei
WEN Hong-juan
WANG Jing
ZHANG Pei-jing
FENG Hui-li
WANG Hui-ling
CHANG Yi-niu
REN Bin-bin
Abstract：Objective To explore the clinical efficacy and mechanism of mirror neuron therapy in the treatment of phase Ⅰ complex regional pain syndrome(CRPS)following stroke.Methods A total of 40 patients with CRPS phaseⅠ were selected from the Rehabilitation Department for this study.The patients were randomly divided into a control group and a mirror therapy group,with 20 patients in each group.Both groups received basic and conventional rehabilitation treatments,while the mirror therapy group additionally received mirror therapy.Treatment was administered twice daily,five times per week,for three weeks.Pain in the shoulder joint was evaluated using the Resting State Visual Analogue Scale(R-VAS)and the Passive Movement State Visual Analogue Scale(P-VAS).Hand swelling was assessed using the water displacement method,and upper limb motor function was evaluated with the Fugl-Meyer scale.Serum levels of calcitonin gene-related peptide(CGRP)and substance P(SP)were measured using ELISA.Results After three weeks of treatment,patients in the mirror therapy group showed lower R-VAS and P-VAS scores,reduced hand swell-ing,and higher Fugl-Meyer scores compared to the control group(P＜0.05).Additionally,the mirror therapy group had lower serum SP levels and higher CGRP levels than the control group(P＜0.05).Conclusion Mirror therapy is more effective in alleviating shoulder joint pain,hand swelling,and upper limb dysfunction in CRPS phase Ⅰ patients,and it regulates serum CGRP and SP levels.
Keywords：strokemirror neuron therapycomplex regional pain syndromestage Ⅰshoulder painsubstance Pcalcitonin gene-related peptide
Publication Date：2024-09-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 1137-1142 )