Changes in bone metabolism index,blood sugar and insulin resistance after anti-thyroid drug treatment in patients with Graves'disease
CHEN Chui-zhe
WU Hua-gui
WANG Xin-jun
WANG Zhuan-suo
Abstract：Objective To observe changes in bone metabolism markers,blood glucose,and insulin resistance in-dex in patients with newly diagnosed Graves'disease after antithyroid drug treatment.Methods A longitudinal study was conducted with 32 newly diagnosed Graves'disease patients over one year.Fasting blood samples were collected before and after 4,8,and 12 months of antithyroid drug treatment.Biochemical methods were used to measure blood glucose,insulin,and bone metabolism markers.A control group of 55 healthy individuals was included for comparison.Results Compared with the healthy control group,before treatment,Graves'disease patients had elevated fasting blood glucose(FBG),insulin,and insulin resistance index(HOMA-IR);decreased blood parathyroid hormone(PTH)levels;and increased blood calcium,PINP,osteocalcin(OC),alkaline phosphatase(ALP),25(OH)D,and β-CTX levels.After 8 months of treatment,fasting blood glucose returned to normal.After 4 months of treatment,blood insulin and HOMA-IR also returned to normal.Blood calcium levels normalized after 4 months of treatment.However,after treatment,ALP,PINP,OC,and β-CTX levels significantly decreased,while PTH levels significantly increased.Conclusion Untreated Graves'disease patients exhibit elevated fasting blood glucose and insulin resistance,which can normalize with antithyroid drug treatment.After 12 months of treatment,serum levels of ALP,PINP,osteocalcin,and β-CTX in Graves'disease patients decreased but had not fully normalized.
Keywords：Graves'diseasebone metabolismglucoseinsulin resistance
Publication Date：2024-09-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 1124-1130 )