Clinical study on the combined treatment of Whole Eucommia Capsules and cannulated screw fixation for Garden Ⅲ-Ⅳ femoral neck fractures
DU Gui-qiang
LIU Li-yun
Abstract：Objective To explore the clinical value of whole Eucommia capsules in the postoperative application of cannulated screw fixation for Garden Ⅲ-Ⅳ femoral neck fractures.Methods A prospective study was conducted on 110 patients with Garden Ⅲ-Ⅳ femoral neck fractures who received cannulated screw fixation from June 2020 to June 2022.The patients were randomly divided into two groups,each with 55 patients:the observation group received whole Eucommia capsules postoperatively,while the control group received conventional treatment for 6 months.Postoperative evaluations included reduction grade,incidences of internal fixation failure,fracture nonunion,and femoral head necrosis.Harris scores were assessed before and after treatment,and serum levels of vascular endothelial growth factor(VEGF),basic fibroblast growth factor(bFGF),and cysteine-aspartic acid protease-3(Caspase-3)were measured.Results Four patients(2 due to non-compliance with medication,2 lost to follow-up)withdrew from the observation group,and four patients(1 due to non-compliance with medication,3 lost to follow-up)withdrew from the control group.There were no statistically significant differences between the two groups in reduction grade,internal fixation failure rate,or frac-ture nonunion rate(P＞0.05).Significant differences were observed in Harris scores and femoral head necrosis rates(P＜0.05),with the observation group showing higher Harris scores and lower femoral head necrosis rates than the con-trol group.After treatment,the observation group showed increased levels of VEGF and bFGF and decreased levels of Caspase-3 compared to pre-treatment(P＜0.05),while the control group showed no significant changes in serum indi-cators(P＞0.05).Conclusion Postoperative treatment with whole Eucommia capsules after cannulated screw fixation for Garden Ⅲ-Ⅳ femoral neck fractures is beneficial for improving joint function and preventing femoral head necrosis.The mechanism may be related to the upregulation of VEGF and bFGF and the downregulation of Caspase-3.
Keywords：femoral neck fracturesfemoral head necrosiswhole Eucommia capsulesVEGFbFGFCaspase-3
Publication Date：2024-08-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1028-1032 )