Risk factors and prognosis of carbapenem-resistant Klebsiella pneumoniae bloodstream infection
LU Meng-di
CAI Yi-han
LING Yon
ZHANG Li-yan
ZHAO Yue
Abstract：Objective To explore the risk factors and clinical prognosis of patients with carbapenem-resistant Klebsiella pneumoniae(CRKP)bloodstream infection in hospital,and provide a scientific basis for the effective control of CRKP bloodstream infection.Methods Adopting a case-control study in a 1:2 ratio,cases of CRKP bloodstream infec-tion in Guangdong Provincial People's Hospital from January 2012 to December 2022 were collected and analyzed through retrospective analysis.Based on the results of the blood culture for 28 days,the CRKP group was divided into a survival group and a death group.Meanwhile,univariate and multivariate logistics regression were applied to analyze the related risk factors of CRKP bloodstream infection and the important risk factors affecting the prognosis of CRKP bloodstream infec-tion in 28 days.Kalan-Meier was employed to plot the survival curve.Results Central venous intubation(P=0.042),other site infections(P=0.028),and previous use of antibiotics(P＜0.001)may be important risk factors for CRKP bloodstream infection in the hospital.Cardiovascular and cerebrovascular diseases(P=0.029)were the main risk factors for patients infected with CRKP dead in 28 days,and the death rate of patients in the CRKP group was significantly higher than that in the carbapenem-sensitive Klebsiella pneumoniae(CSKP)group(P＜0.001).Conclusion The high fatali-ty rate of CRKP bloodstream infection seriously affects the prognosis of patients.Hence,the clinic should endeavor to pro-tect patients from infection,reduce the occurrence of CRKP bloodstream infection,and curb the spread of CRKP in hospital.
Keywords：carbapenem-resistant Klebsiella pneumoniaebloodstream infectionrisk factorsclinical prognosis
Publication Date：2024-08-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 981-987 )