Effect of adding GnRHa to luteal support in antagonist protocols on pregnancy outcomes in IVF-ET
QIN Jin-chun
ZHANG Yi-sheng
CHI Yan
HUANG Tai-shuai
XIA Xiao-ling
QIN Jie
Abstract：Objective To elucidate the role of triptorelin acetate(GnRHa)in luteal support during antagonist protocols for in vitro fertilization-embryo transfer(IVF-ET).Methods A retrospective analysis was conducted using 1:1 propensity score matching on 146 patient records from November 2021 to December 2022 at our center.Patients were divided into two groups based on their luteal support regimen.The control group(n=73)received standard luteal sup-port,while the GnRHa group(n=73)received standard luteal support plus GnRHa.Baseline characteristics and preg-nancy outcomes were compared between the groups(P＞0.05).Results There were no significant differences in base-line characteristics between the groups.The proportion of high-quality embryos was significantly lower in the GnRHa group compared to the control group(73.43％vs.83.33％,P=0.041).However,compared to the control group,the GnRHa group showed increased implantation rates,clinical pregnancy rates,multiple pregnancy rates,ongoing pregnancy rates,and live birth rates,while the biochemical pregnancy rates and early miscarriage rates were decreased.These differ-ences were not statistically significant(P＞0.05).Conclusion Adding GnRHa to luteal support in antagonist protocols may be beneficial.However,large-scale multicenter randomized controlled trials(RCTs)are required to further clarify the advantages and disadvantages of this approach across different patient populations before widespread clinical application.
Keywords：antagonist regimenGnRHaluteal supportIVF-ET
Publication Date：2024-08-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 976-980 )