Mitochondria-related gene expression changes are associated with cancer-related fatigue in patients with cervi-cal cancer receiving synchronous radiotherapy and chemotherapy
DAN Xin
HE Ya-lin
TIAN Ya-lin
WU Hong-ying
Abstract：Objective To explore the dynamic changes in cancer-related fatigue(CRF)and its relationship with mitochondrial-related gene expression in cervical cancer patients undergoing concurrent chemoradiotherapy(CCRT).Methods A prospective longitudinal study was conducted from May 2021 to October 2022 at West China Sec-ond Hospital,Sichuan University,involving 84 cervical cancer patients undergoing CCRT,with 42 patients in both the ob-servation and control groups.CRF scores,depression scores,and six peripheral blood samples(pre-treatment and after the 1st-5th CCRT)were collected and compared with baseline data from the control group.Repeated measures,mito-chondrial PCR arrays,and mixed linear models were used to analyze the trends in CRF at different treatment times,differ-ential expression of mitochondrial-related genes,and their relationship with CRF.Results Compared to baseline,CRF worsened with increasing CCRT sessions(F=8.254,P=0.036).Eight mitochondrial genes(EHD1,FIS1,SORL1,CXCR1,GAPDH,RAC2,ACTB,and BCL2L1)were upregulated by more than 3-fold,while five genes(MTOR,PDK3,NSD1,MIPEP,and MSTO1)were downregulated by more than 5-fold.Nine mitochondrial genes(CXCR1,GAPDH,SORL1,MTOR,FIS1,EHD1,PDK3,NSD1,and MIPEP)showed a close association with CRF.Conclusion This study preliminarily identified nine mitochondrial genes associated with CRF,providing references for developing targeted drugs for CRF or formulating targeted nursing interventions.
Keywords：cervical cancerchemotherapyradiotherapycancer-related fatiguemitochondriagene expression
Publication Date：2024-06-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 782-788 )