Comparative analysis of clinical efficacy between fluticasone furoate/umeclidinium/vilanterol triple therapy and traditional ICS/LAMA therapy in patients with asthma-COPD overlap
ZHANG Yong
DANG Yao
CHEN Ping
LIU Yuan-ming
Abstract：Objective To evaluate the clinical efficacy of fluticasone furoate/umeclidinium/vilanterol(FF/UMEC/VI)triple therapy in patients with asthma-chronic obstructive pulmonary disease(COPD)overlap(ACO)and its differences compared to the traditional inhaled corticosteroid(ICS)/long-acting muscarinic antagonist(LAMA)com-bination therapy.Methods Ninety ACO patients admitted to the Department of Respiratory and Critical Care Medicine from June 2019 to June 2022 were randomly divided into a study group and a control group,with 45 patients in each group.The control group received ICS/LAMA treatment,while the study group received FF/UMEC/Ⅵ triple therapy.Af-ter 12 weeks of treatment,changes in lung function indicators,symptom improvement,and treatment efficacy were com-pared between the two groups.Results Before treatment,there were no significant differences in baseline clinical data and various lung function indicators between the study group and the control group(P＞0.05).After 12 weeks of treat-ment,the study group showed significant improvements in various lung function and blood gas analysis indicators compared to before treatment(P＜0.05).Different treatment regimens revealed that the study group had a higher degree of im-provement in various lung function parameters than the control group(P＜0.05)after 12 weeks of treatment.Symptom improvement indicators and treatment effectiveness were also higher in the study group than in the control group after 12 weeks of treatment(P＜0.05).Conclusion FF/UMEC/Ⅵ triple therapy demonstrates significant therapeutic effects in ACO patients,improving lung function and relieving clinical symptoms.This therapy holds promising prospects for broader clinical applications.
Keywords：asthma-chronic obstructive pulmonary disease overlap syndromefluticasone furoateumeclidini-umvilanterol
Publication Date：2024-06-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 751-756 )