Changes in serum Lp-PLA2and NLR levels and their clinical significance in patients with coronary slow flow
LIU Ya-nan
FANG Zhi-qin
GUO Jian-hong
WANG Ya-ling
Abstract：Objective To investigate the levels of serum lipoprotein-associated phospholipase A2(Lp-PLA2)and the neutrophil-to-lymphocyte ratio(NLR)in patients with coronary slow flow(CSF)and their clinical signifi-cance.Methods From December 2022 through August 2023,45 patients with coronary slow flow verified by coronary angiography(CAG)at the First Affiliated Hospital of Hebei North University served as the observation group(CSF group).Simultaneously,45 individu This study included 45 patients diagnosed with CSF via coronary angiography(CAG)from December 2022 to August 2023 at the First Affiliated Hospital of Hebei North University as the observation group(CSF group).Another 45 patients with normal coronary blood flow indicated by CAG during the same period were selected as the control group.Serum Lp-PLA2 and NLR levels were compared between the two groups.A multivariate logistic re-gression model was used to analyze the influencing factors for CSF.Receiver operating characteristic(ROC)curves were drawn to evaluate the diagnostic efficacy of serum Lp-PLA2 and NLR for CSF.Results The levels of serum Lp-PLA2[(25.33±4.02)μg/L vs.(22.29±4.07)μg/L]and NLR[2.61(2.11,3.25)vs.1.54(1.19,1.86)]in the CSF group were significantly higher than those in the control group(both P＜0.05).Multivariate logistic regression indi-cated that elevated serum Lp-PLA2(OR=1.210,95％CI:1.015-1.442,P＜0.05)and NLR(OR=35.826,95％CI:5.565-230.638,P＜0.01)were independent risk factors for CSF.Further ROC curve analysis showed that the crit-ical value for diagnosing CSF with serum Lp-PLA2 was 23.127 µg/L,with an area under the ROC curve(AUC)of 0.699(95％CI:0.591-0.807,P＜0.05),sensitivity of 0.756,and specificity of 0.600.For NLR,the critical value for diagnosing CSF was 2.074,with an AUC of 0.907(95％CI:0.845-0.969,P＜0.01),sensitivity of 0.800,and specificity of 0.911.The AUS of the combined diagnosis of Lp-PLA2 and NLR was 0.933(95％CI:0.884-0.982,P＜0.01),with sensitivity of 0.867,and specificity of 0.889.Conclusion Elevated levels of serum Lp-PLA2 and NLR are observed in CSF patients,and both are independent risk factors for CSF.These markers have certain diagnostic value for CSF.
Keywords：coronary slow flowneutrophil to lymphocyte ratiolipoprotein associated phospholipase A2
Publication Date：2024-06-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 717-722 )