Comparison of ciprofol and propofol anesthesia maintenance in elderly patients undergoing laparoscopic radical surgery for colorectal cancer
GAN Chuan
PENG Wei-long
HUANG Jing-xiang
CHEN Jian
CAI Lian-jie
CAO Yang
Abstract：Objective To investigate the use of ciprofol versus propofol anesthesia maintenance in elderly patients undergoing laparoscopic radical surgery for colorectal cancer.Methods A total of 80 elderly patients undergoing laparo-scopic radical colorectal cancer surgery were included and randomly divided into observation and control groups,with 40 patients in each group.The observation group received ciprofol for anesthesia maintenance,while the control group re-ceived propofol.The levels of inflammatory factors,hemodynamic indicators,MMSE scores,and adverse reactions at dif-ferent time points were compared between the two groups.Results HR,SBP,and DBP in both groups showed a decrea-sing trend from T1 to T4 and an increasing trend from T4 to T7,with significant differences within the groups(P＜0.05).Comparatively,SBP,and HR at T4,T5,T6,and T7 in the control group were higher than those in the observation group(P＜0.05).The induction time,awakening time,and extubation time in the observation group were lower than those in the control group(P＜0.05).At 24 hours post-surgery,levels of interleukin-6(IL-6)and tumor necrosis factor-alpha(TNF-α)in the observation group were lower than those in the control group(P＜0.05).The incidence of com-plications in the observation group was 2.50％(1/40),significantly lower than 25.00％(10/40)in the control group(P＜0.05).MMSE scores at D1,D3,and D5 were higher in the observation group compared to the control group,with significant differences between the groups(P＜0.05).Conclusion The ciprofol anesthesia maintenance in elderly pa-tients undergoing laparoscopic radical colorectal cancer surgery has a better effect compared to propofol.It results in less impact on hemodynamics,lower postoperative inflammatory factor levels,fewer adverse reactions,and less impact on post-operative MMSE scores.
Keywords：ciprofolpropofolanesthesia maintenancelaparoscopic radical resection of colorectal cancer in the elderly
Publication Date：2024-06-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 706-711 )