Expression levels of sdLDLC,SAA,PAF in acute coronary syndrome and their relationship with vulnerable plaques
NIU Fu-ying
ZHENG Zhao-xia
LUO Jing-hui
LI Li
LI Qing
Abstract：Objective To investigate the expression levels of small dense low-density lipoprotein cholesterol(sdLDLC),serum amyloid A(SAA),and platelet-activating factor(PAF)in acute coronary syndrome(ACS)and their relationship with vulnerable plaques.Methods A total of 136 patients with coronary heart disease were divided into stable angina pectoris(SAP)group(n=45)and ACS group(n=91).Based on plaque stability,they were further di-vided into stable plaque group(n=53)and vulnerable plaque group(n=83).Differences in sdLDLC,SAA,PAF lev-els,and plaque characteristics were measured.Results Compared with the SAP group,the ACS group had a higher pro-portion of male gender,smoking history,levels of white blood cell(WBC),triglyceride(TG),uric acid,creatinine,sdLDLC,SAA,and PAF,and lower level of HDL-C(P＜0.05).The ACS group showed significantly larger necrotic core(NC),lipid pool area(LPA),plaque lipid ratio(PLR),eccentric index(EI),remodeling index(RI),plaque burden(PB)compared to the SAP group(P＜0.05).There were statistically significant differences in the expression levels of sdLDLC,SAA,and PAF between the stable plaque group and the vulnerable plaque group(P＜0.05).Pearson correlation analysis showed that sdLDLC,SAA,and PAF were positively correlated with NT,LPA,PLR,EI,RI,PB(P＜0.05).Multivariate logistic regression analysis revealed that sdLDLC,SAA,and PAF were independent predictors of vulnerable plaques(P＜0.05).Conclusion Levels of sdLDLC,SAA,and PAF are significantly elevated in ACS pa-tients and are closely related to vulnerable plaques.
Keywords：acute coronary syndromevulnerable plaquessmall and dense low density lipoprotein cholesterolserum amyloid Aplatelet activating factor
Publication Date：2024-05-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 626-630 )