Manifestation of gastric emptying disorders in early Parkinson's disease patients on gastrointestinal ultrasonogra-phy
DONG Xiao-meng
LI Bin
CHEN Lian-xiang
SONG Xiao-wen
WANG Hong-cai
SU Yi-peng
Abstract：Objective To investigate the manifestation of non-motor symptoms,specifically gastric emptying disorders,in early Parkinson's disease(PD)patients using gastrointestinal ultrasonography.Methods Thirty-two out-patients and inpatients diagnosed with early Parkinson's disease(Hoehn and Yahr stage Ⅰ-Ⅲ)with symptoms of gastric emptying disorders(including nausea,vomiting,early satiety,and postprandial bloating)(PD group)and 30 healthy participants undergoing physical examinations during the same period(control group)underwent gastrointestinal ultra-sonography.Gastric motility parameters including antral contraction amplitude(AC A),antral contraction frequency(ACF),gastric motility index(GMI),gastric emptying rate(GER),gastric emptying time(GET),gastric wall thick-ening rate,and gastric peristaltic wave velocity were recorded and measured at different time points(0-120 min)after ingestion of the contrast agent.Results The values of ACA,ACF,GMI,and GER in the PD group were lower than those in the control group at each time point(P＜0.01,P＜0.05).Gastric emptying time was significantly longer in the PD group compared to the control group(P＜0.01).At 30 minutes,the gastric wall thickening rate and gastric peristaltic wave velocity in the PD group were lower than those in the control group(P＜0.01).Conclusion Gastric emptying dis-orders in early Parkinson's disease patients can be effectively evaluated using gastrointestinal ultrasonography.
Keywords：the early stage of Parkinson's diseasegastric emptying disorderscontrast-enhanced ultrasound
Publication Date：2024-04-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 510-515 )