Effect of metformin combined with ethinylestradiol and cyproterone acetate tablets on the shift of serum miR-124 and Th1/Th2 cytokine balance in patients with polycystic ovary syndrome
HU Yan-mei
WANG Jie
WU Xue-yi
Abstract：Objective To investigate the effects of metformin combined with ethinylestradiol and cyproterone ace-tate tablets on serum miR-124 levels and Th1/Th2 cytokine balance shift in patients with polycystic ovary syndrome(PCOS).Methods A total of 200 PCOS patients treated at Panzhihua Maternal and Child Health Hospital from January 2022 to February 2023 were included and divided into an observation group(n=100)and a control group(n=100).The observation group received metformin combined with ethinylestradiol and cyproterone acetate tablets,while the control group received ethinylestradiol and cyproterone acetate tablets alone.The treatment duration was 3 months.Clinical data,lipid levels[total cholesterol(TC),triglyceride(TG),low density lipoprotein-C(LDL-C)],fasting plasma glucose(FPG),fasting serum insulin(FINS),and homeostasis model assessment-IR(HOMA-IR)were collected before and after treatment.Serum miR-124,interlenkin(IL)-2,IL-6,and interferon-γ(INF-γ)were also measured.Results After treatment,TG,TC,and LDL-C levels in the observation group significantly decreased(P＜0.05).Post-treatment TG,TC,and LDL-C levels in the observation group were lower than those in the control group(P＜0.05).There were no statistically significant differences in FPG,FINS,and HOMA-IR between the two groups before treatment(P＞0.05).After treatment,FPG,FINS,and HOMA-IR levels in the observation group significantly decreased(P＜0.05),and these levels were lower than those in the control group(P＜0.05).There were no significant differences in IL-2,IL-6,INF-γ,and miR-124 levels between the two groups before treatment(P＞0.05).After treatment,IL-6 and INF-γ levels decreased,and IL-2 and miR-124 levels increased in the observation group(P＜0.05).Post-treatment IL-6 and INF-γ levels were lower,while IL-2 and miR-124 levels were higher in the observation group compared to the control group(P＜0.05).Conclusion Metformin combined with ethinylestradiol and cyproterone acetate tablets can significantly improve insulin resistance,regulate glucolipid metabolism and improve the state of Th1/Th2 cytokine balance s hift in PC OS patients.
Keywords：metforminpolycystic ovary syndromemiR-124Th1/Th2 balance
Publication Date：2024-04-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 499-504 )