Influence of intestinal flora abundance on early prognosis of diabetes recipients after kidney transplantation
HAN Jian-le
WANG Xiao-bo
YANG Shuai-ping
YANG Jun-wei
YANG Qing-yan
LI Tao
SUO Jing-jun
YIN Zheng-wei
WANG Chang-an
Abstract：Objective To investigate the effect of intestinal flora abundance on early prognosis of diabetes recipi-ents after kidney transplantation.Methods The clinical data of 150 patients with diabetes who underwent renal trans-plantation were retrospectively analyzed.The patients divided into rejection group(n=42)and non-rejection group(n=108)according to whether there was rejection after surgery.Gut microbiota,renal function,and immune response were compared between the two groups,and the relationship between their changes and post-kidney transplantation rejec-tion reactions was analyzed.Results The abundance of Bifidobacterium,Lactobacillus,and Clostridium in the rejection group was lower than that in the non-rejection group,while the abundance of Enterobacter and Enterococcus was higher(P＜0.05).Urea nitrogen,blood creatinine,cystatin C,and lymphocyte response in the rejection group were higher than those in the non-rejection group(P＜0.05).Pearson correlation analysis showed that the abundance of Bifidobacterium,Lactobacillus,and Clostridium was negatively correlated with post-kidney transplantation rejection reactions(r=-0.612,-0.635,-0.607,P＜0.05),while the abundance of Enterobacter and Enterococcus,as well as urea nitro-gen,blood creatinine,cystatin C,and lymphocyte response,was positively correlated(r=0.627,0.656,0.639,0.688,0.624,0.671,P＜0.05).Multivariate logistic regression analysis showed that the abundance of Bifidobacteri-um,Lactobacillus,Clostridium,Enterobacter,Enterococcus,as well as urea nitrogen,blood creatinine,cystatin C,and lymphocyte response were all risk factors for post-kidney transplantation rejection reactions(OR=4.536,4.651,4.473,4.637,4.707,5.140,4.918,4.973,5.083,P＜0.05).Receiver operating characteristic(ROC)curve anal-ysis showed that the abundance of Bifidobacterium,Lactobacillus,Clostridium,Enterobacter,Enterococcus,as well as u-rea nitrogen,blood creatinine,cystatin C,and lymphocyte response had high predictive value for post-kidney transplan-tation rejection reactions.Conclusion Gut microbiota,renal function,and immune response are closely related to post-kidney transplantation rejection reactions,which can guide the formulation of reasonable diagnosis and treatment plans in clinical practice to reduce kidney transplantation rejection reactions.
Keywords：diabetesrenal transplantationintestinal florarenal functionimmune reactionrejection reaction
Publication Date：2024-04-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 447-452 )