Application of combined measurement of CgA,TNF-α,IL-6,and modified qSOFA score in the prognostic as-sessment of pediatric sepsis

CUI Jun-hao; GU Xue; WANG Yang-ji; SONG Chun-lan

doi:10.13820/j.cnki.gdyx.20232865

Abstract：Objective To evaluate the application of combined measurement of chromogranin A(CgA),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),and modified quick Sequential Organ Failure Assessment(qSO-FA)score in the prognostic assessment of pediatric sepsis.Methods Clinical data of 188 pediatric sepsis patients ad-mitted to our hospital from March 2020 to April 2023 were selected.The patients were divided into sepsis group(n=113)and severe sepsis group(n=75)based on the severity of their condition.CgA,TNF-α,and IL-6 levels were com-pared between the two groups.The relationship between CgA,TNF-α,IL-6 levels,modified qSOFA score,and the prognosis of children was analyzed to explore their predictive value for the prognosis of children.Results CgA,TNF-α,IL-6,and modified qSOFA scores in the severe sepsis group were higher than those in the sepsis group(P＜0.05).Pa-tients in the deceased group had higher CgA,TNF-α,IL-6,and modified qSOFA scores compared to the survival group(P＜0.05).Using the prognosis of children as the independent variable(survival=0,death=1),multiple logis-tic regression analysis of CgA,TNF-α,IL-6,and modified qSOFA scores showed that these indicators would impact the prognosis of children(P＜0.05).The AUC values of receiver operating characteristic(ROC)curves for predicting adverse prognosis in patients using CgA,TNF-α,IL-6,and modified qSOFA scores were 0.926,0.875,0.863,0.862,respectively.The AUC value of combined application was 0.994,higher than individual predictions(P＜0.05).Conclusion Combined measurement of CgA,TNF-α,IL-6,and modified qSOFA scores significantly increases in pe-diatric patients with severe sepsis and deceased patients.Their combined application has a high predictive value for ad-verse prognosis in children,assisting in the clinical treatment of pediatric sepsis.