Clinical significance of inflammatory factors,coagulation and carbohydrate antigen 125 in moderate to severe ovarian endometriosis cyst

LI Lei; ZHANG Xiao-lu; YAN Hong-lin; HONG Bo; HUANG Yan-yu

doi:10.13820/j.cnki.gdyx.20232767

Abstract：Objective To explore the clinical significance and diagnostic value of inflammatory factors,coagula-tion and carbohydrate antigen 125(CA125)in moderate to severe ovarian endometriosis cyst.Methods A retrospective analysis was conducted on clinical data from 127 patients with stage Ⅲ and Ⅳ ovarian endometriotic cysts(endometriosis group)and 101 patients with other benign ovarian cysts treated at Shenzhen Second People's Hospital from January to De-cember,2021.The differences in inflammatory factors,coagulation function,and CA125 between the two groups were compared.Receiver operating characteristic(ROC)curves were drawn,and the diagnostic value of relevant indicators for moderate to severe ovarian endometriosis was analyzed.Results In the endometriosis group,the neutrophil-to-lym-phocyte ratio(NLR)and platelet-to-lymphocyte ratio(PLR)were significantly higher than those in the control group(P＜0.05).Plasma fibrinogen(FIB)was significantly higher in the endometriosis group(P＜0.05).Thrombin time(TT)was significantly shorter in the endometriosis group(P＜0.05).CA125 and human epididymis protein 4(HE4)were significantly higher in the endometriosis group(P＜0.05).There were no significant differences between the two groups in lymphocyte-to-monocyte ratio(LMR),platelet count(PLT),prothrombin time(PT),and activated partial thromboplastin time(APTT)(P＞0.05).Combined detection of CA125 and NLR can increase the sensitivity of diagnosis to 89.0％.Conclusion Patients with moderate to severe ovarian endometriosis exhibit changes in inflammatory factors and elevated fibrinogen.Combined detection of CA125 and NLR has clinical value in the diagnosis of moderate to severe ovarian endometriosis.