Relationship between peripheral blood miR-27a and miR-146a-5p levels and pregnancy outcome in patients with gestational diabetes mellitus
TANG Qian-qian
ZHANG Qing
WANG Yan
LI Ai-ping
Abstract：Objective To ivnestigate the correlations between peripheral blood micro ribonucleic acid-27a(miR-27a)and micro ribonucleic acid-146a-5p(miR-146a-5p)levels and pregnancy outcomes in patients with gestation-al diabetes mellitus(GDM).Methods Sixty GDM patients admitted to the Department of Obstetrics and Gynecology at the Second Affiliated Hospital of Zhengzhou University from January 2020 to December 2022 were retrospectively selected as the study subjects.Based on pregnancy outcomes,they were divided into adverse outcome group(n=29)and good outcome group(n=31).Single-factor analysis and logistic multivariate regression analysis were performed on the clini-cal data of the two groups.Spearman correlation analysis was used to analyze the correlation between peripheral blood miR-27a,miR-146a-5p levels,and pregnancy outcomes.Receiver Operating Characteristic(ROC)curve analysis was conducted to assess the predictive value of miR-27a and miR-146a-5p for pregnancy outcomes in GDM patients.Results There were significant differences in TC,TG,miR-27a,and miR-146a-5p between the two groups(P＜0.05).Logistic multivariate regression analysis revealed that miR-27a and miR-146a-5p were risk factors for adverse pregnancy outcomes in GDM patients(P＜0.05).Spearman correlation analysis showed a positive correlation between pe-ripheral blood miR-27a levels and adverse pregnancy outcomes,while peripheral blood miR-146a-5p levels were neg-atively correlated with adverse pregnancy outcomes(P＜0.05).The ROC curve indicated that the AUC for predicting pregnancy outcomes in GDM patients was 0.915 for miR-27a,0.902 for miR-146a-5p,and the AUC was maximized when combined,reaching 0.979.Conclusion Peripheral blood levels of miR-27a and miR-146a-5p are associated with adverse pregnancy outcomes,and their combined detection has high predictive value for pregnancy outcomes in GDM patients,facilitating early assessment of pregnancy outcomes.
Keywords：micro ribonucleic acid-27amicro ribonucleic acid-146a-5pgestational diabetes mellituspregnancy outcomecorrelationpredictive value
Publication Date：2024-03-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 361-365 )