Correlation between vitamin D and insulin resistance in newly diagnosed type 2 diabetes patients

SUN Yan; LI Qing-hua; LIAO Hui-min; DENG Ai-ping; LIU Zhu-fen; LI Wan-mei

doi:10.13820/j.cnki.gdyx.20234850

Abstract：Objective To investigate the correlation between 25-hydroxyvitamin D3[25(OH)D3]levels and in-sulin resistance,urine pH,and other factors in newly diagnosed type 2 diabetes mellitus(T2DM)patients.Methods The levels of 25(OH)D3 were measured in 325 non-diabetic patients(normal control group,n=325)and 208 newly di-agnosed T2DM patients(newly diagnosed T2DM group,n=208).Based on the levels of 25(OH)D3,newly diagnosed T2 DM patients were divided into vitamin D deficiency group(n=92)and non-deficiency group(n=116).The level of 25(OH)D3 was considered deficient if it was＜20 ng/mL and sufficient if it was 20-100 ng/mL.The correlation be-tween 25(OH)D3 and insulin resistance,urine pH,etc.,was analyzed using SPSS 26.0.Results The level of 25(OH)D3 in the newly diagnosed T2DM group was higher than that in the normal control group(P＜0.01);the age,glycated hemo-globin,insulin resistance index,urine pH,free triiodothyronine(FT3),and free thyroxine(FT4)in the deficiency group were higher than those in the non-deficiency group(P＜0.05),while there was no statistically significant difference in pancreatic function index,fasting C-peptide,serum calcium,and thyroid-stimulating hormone(TSH)between the two groups(P＞0.05).Logistic regression analysis showed that glycated hemoglobin(OR=1.776,P＜0.05)and insulin resistance index(OR=1.289,P＜0.05)were risk factors for vitamin D deficiency in newly diagnosed T2DM patients.Conclusion The level of 25(OH)D3 in the newly diagnosed T2DM group was lower than that in the normal control group.Higher glycated hemoglobin and insulin resistance index are risk factors for vitamin D deficiency in patients with T2DM.