Investigation of CO VID-19 infection status and analysis of prognostic factors in a single-center maintenance he-modialysis cohort
WANG Yan-jiang
WANG Hai-lin
YUAN Shan
YUAN Xin-zhu
XIE Xi-sheng
FENG Sheng-gang
Abstract：Objective To investigate the incidence of COVID-19 infection in maintenance hemodialysis(MHD)patients and analyze factors influencing prognosis,providing insights for improved management of MHD patients.Methods A total of 280 MHD patients were systematically sampled for the investigation of COVID-19 infection inci-dence.Those infected were categorized into recovery and death groups based on prognosis,with relevant factors investiga-ted.Results Among 265 MHD patients with COVID-19 infection(94.64％incidence),15 deaths occurred,yielding a mortality rate of 5.66％.Asymptomatic infections were observed in 30 patients(11.32％).The death group(n=15)exhibited higher proportions of fatigue,poor appetite,cough,sore throat,and difficulty breathing compared to the recovery group(n=250)(P＜0.05).The recovery group showed a higher proportion of muscle soreness compared to the death group(P＜0.05).No significant differences were noted in fever,anosmia,ageusia,dizziness,headache,and diarrhea percentages(P＞0.05).Additionally,no marked distinctions were found in primary diseases,COVID-19 vaccination doses,dialysis vintage,blood phosphate,parathyroid hormone,interdialytic weight gain,hemoglobin,fasting blood glu-cose,and blood pressure between the groups(P＞0.05).The death group,however,had higher proportions of diabetes,post-COVID-19 viral pneumonia,less exercise during dialysis intervals,older age,lower blood calcium,elevated in-flammatory indicators(white blood cell count,C-reactive protein,parathyroid hormone,interleukin-6),and more in-stances of substandard single-pool urea clearance index(spKt/V)(P＜0.05).Conclusion Major factors influencing death in MHD patients with COVID-19 infection include diabetes,post-COVID-19 viral pneumonia,lack of exercise during dialysis intervals,advanced age,low blood calcium,elevated inflammatory indicators,and substandard spKt/V.Encouraging exercise during dialysis intervals and improving dialysis adequacy can enhance the prognosis of MHD patients with COVID-19 infection.
Keywords：hemodialysisnovel coronavirus infectionprognosisinfluencing factorsvaccinationexercise be-tween dialysisviral pneumonia
Publication Date：2024-02-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 241-247 )