A study on the correlations between bronchopulmonary dysplasia in preterm infants,long-term pulmonary function,and vitamin d levels at birth
LU Tian-tian
MAI Wen-hui
WANG Dan-hong
LIU Min
CHEN Xiu-ling
JIA Yan-ping
Abstract：Objective To analyze the relationship between vitamin D levels at birth and the development of bron-chopulmonary dysplasia(BPD)and long-term pulmonary function in preterm infants.Methods A total of 120 preterm infants admitted to the neonatal intensive care unit(NICU)between June 2018 and March 2020 were included in this study.Serum vitamin D levels were measured in all preterm infants at birth.Follow-up assessments were conducted when the infants reached 2 years of age,during which pulmonary function parameters,including TPTEF/TE,VPTEF/VE,and PEF,were measured.Spearman correlation analysis was used to assess the relationship between serum vitamin D levels and the development of BPD,while Pearson correlation analysis was used to evaluate the association between serum vita-min D levels at birth and pulmonary function parameters at 2 years of age.Results Compared to preterm infants in the non-BPD group,those in the BPD group had significantly lower serum vitamin D levels(P＜0.05).Serum vitamin D levels varied significantly among infants with different BPD severity levels(P＜0.05),with progressively lower levels ob-served in more severe cases.At 2 years of age,preterm infants in the BPD group exhibited significantly lower pulmonary function parameters,including TPTEF/TE,VPTEF/VE,and PEF,compared to those in the non-BPD group(P＜0.05).Significant differences in these pulmonary function parameters were also observed among infants with varying BPD severity levels(P＜0.05),with greater disease severity corresponding to lower pulmonary function parameters.There was a significant negative correlation between serum vitamin D levels at birth and the development of BPD(r=-0.659,P＜0.05).Moreover,serum vitamin D levels at birth were positively correlated with pulmonary function parameters at 2 years of age,including TPTEF/TE,VPTEF/TE,and PEF(r=0.254,0.232,0.265,P＜0.05).Conclusion Serum vita-min D levels at birth are closely associated with the development of BPD and long-term pulmonary function in preterm in-fants.Vitamin D deficiency at birth can be used to assess the progression of BPD and predict the long-term prognosis of affected infants.
Keywords：preterm infantsbronchopulmonary dysplasialung functionvitamin D
Publication Date：2024-02-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 166-170 )