Impact of gut microbiota on the onset of pre-eclampsia
WANG Xiao-yan
LI Lian-ying
WANG Yan-xia
ZHANG Han-ru
LIU Ting-ting
Abstract：Objective To elucidate the influence of gut microbiota on the pathogenesis of pre-eclampsia(PE)and investigate the underlying mechanisms.Methods A cohort of 40 PE patients and 40 healthy pregnant women,ad-mitted to the Department of Obstetrics and Gynecology at Gansu Maternal and Child Health Hospital from January 2021 to June 2022,constituted the study population.Participants were categorized into four groups based on different gestational periods:Group A1(PE patients at 26 weeks,n=20),Group A2(PE patients at 36 weeks,n=20),Group B1(healthy pregnant women at 26 weeks,n=20),and Group B2(healthy pregnant women at 36 weeks,n=20).Morning fecal samples were collected from all groups,and bacterial DNA was extracted for 16S rDNA amplification and sequencing to as-sess gut microbiota alpha diversity and differential composition.Results Chao1 and Observed-Species indices in Group B2 were significantly lower than those in Group B1(P＜0.001).Compared to Group B1,Group B2 exhibited increased abundance of Clostridium,Fournierella,Prevotella,and Fusobacterium,along with decreased abundance of Bifidobacteri-um and Faecalibacterium.Group A1 demonstrated lower Chao1 and Observed-Species indices than Group B1(P＜0.001),displaying analogous microbial composition changes as observed in Group B2.Similar patterns were noted in Group A2 compared to Group B2.Furthermore,Group A2 displayed lower Chao1 and Observed-Species indices than Group A1(P＜0.001),with comparable shifts in microbial composition.Conclusion In healthy pregnant women,a re-duction in gut microbiota alpha diversity occurs with advancing gestational weeks,resulting in an increase in pathogenic bacteria.The gut microbiota of PE patients exhibits higher pathogenicity than that of healthy pregnant women,character-ized by reduced alpha diversity.Additionally,as gestational weeks increase in PE,gut microbiota alpha diversity decrea-ses,pathogenic bacteria increase,and beneficial bacteria decrease.Vigilant monitoring of the gut microbiota in PE indi-viduals holds paramount importance for the prevention of inflammatory diseases.
Keywords：preeclampsiaintestinal floraα diversitypathogenic bacteriabeneficial bacteria
Publication Date：2024-02-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 133-138 )