Analysis of pregnancy outcomes in 134 patients with undifferentiated connective tissue disease
DING Ling
HE Shan-zhi
ZHOU Chan-juan
WANG Ming-xia
WANG Min
YAN Si-yu
ZENG Han-jiang
Abstract：Objective To investigate the influence factors of premature birth or abortion in pregnant patients with undifferentiated connective tissue disease(UCTD).Methods Data of 134 pregnant patients with UCTD from January 1st,2017 to December 31st,2021 were retrospectively analyzed and were divided into premature birth/abortion group(n=38)and mature birth group(n=96).Risk factors of premature birth or abortion were investigated by comparing the clini-cal records,medications and clinical examinations between these two groups.Results Univariate logistic analysis showed that the odd ratio(OR)of using hydroxychloroquine or using low-dose glucocorticoid to predict premature birth or abor-tion in pregnant patients with UCTD was 0.30(95％CI:0.13-0.67)and 0.43(95％CI:0.20-0.92),respectively,suggesting that using hydroxychloroquine and low-dose glucocorticoid may reduce the risk of premature birth or abortion.Multivariate logistic analysis showed that using hydroxychloroquine was an independent protective factor of abortion or pre-term birth(OR=0.297,95％CI:0.134-0.658).Conclusion Using hydroxychloroquine and low-dose glucocorti-coid may reduce the risk of abortion or premature birth in pregnant patients with UCTD.
Keywords：undifferentiated connective tissue diseasepregnancyabortionpreterm birth
Publication Date：2024-01-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 29-34 )