A cohort study of lupus nephritis patients in remission and its associated factors:a real-world study of 58 hospi-tal patients
XU Shui-ming
LI Zheng-tong
YANG Qing-yuan
LIU Yao-xiu
ZENG Guo-xing
WU Jing
Abstract：Objective To investigate the 12-month renal remission in patients with lupus nephritis(LN)and the predictive factors.Methods The remission of patients with LN using biologic agents was analyzed by a prospective cohort study that included 57 patients with LN and positive urine protein,who were divided into hormone+immunosup-pression group(n=39)and hormone+immunosuppression+biologics group(n=18).Patients in hormone+immu-nosuppression group received standard therapy and those in hormone+immunosuppression+biologics group received standard therapy and belimumab.Long-term follow-up was assigned to collect and analyze data on renal response and clinical characteristics.Results Renal complete remission was achieved in 41 out of 57 patients(71.93％)and partial remission was achieved in 16 patients(28.07％).Complete remission was achieved in 29 out of 39 patients in the hor-mone+immunosuppression group(mean time to complete remission was 7.846 months,95％CI:6.626-9.066 months)and in 12 out of 18 patients in the hormone+immunosuppression+biologics group(mean time to complete re-mission was 4.167 months,95％CI:3.461-4.872 months).Conclusion Patients using both hormones,immune agents and biologics achieve complete remission more quickly than those using only hormones and immune agents.
Keywords：lupus erythematosuslupus nephritisbiologic agentsbelimumabcomplete remission
Publication Date：2024-01-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 23-28 )