The correlation between inflammation in MRI of sacroiliac joint and peripheral blood lymphocytes in patients with ankylosing spondylitis
TU Liu-dan
YANG Ming-can
WEI Qiu-jing
WANG Xiao-hong
LIN Chu-rong
GU Jie-ruo
Abstract：Objective To investigate the correlation between lymphocyte subsets in peripheral blood and inflam-mation in MRI of sacroiliac joint in ankylosing spondylitis(AS)patients.Methods Forty-two patients with AS were selected as study group,and 57 healthy controls similar in gender and age were selected as control group.The proportion of T cell and B cell subsets in peripheral blood of these two groups was compared.Patients with AS were divided into in-flammatory group and non-inflammatory group according to edema in SIJ MRI,and the differences of immune cell pheno-types were compared.Results Compared with the healthy controls,the proportions of Th17 cells,Tfh17 cells and Th17/Th2 cells in study group were significantly increased,while the proportion of Th1 and Tfh1 cells was decreased.For AS patients,the proportion of naive CD4+T cells in inflammation group was higher when compared with non-inflammation group;while the failed CD4+T cells,functional CD4+T cells and effective memory CD4+T cells were lower in the non-inflammation group.Conclusion There is imbalance of immune cells in patients with AS.CD4+T cell subsets in periph-eral blood is correlated to edema of sacroiliac joint.
Keywords：ankylosing spondylitislymphocyte subsetsMRI inflammation
Publication Date：2024-01-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 17-22 )