Application of bone turnover markers in the diagnosis and treatment of osteoporosis
QIU Min-li
GU Jie-ruo
Abstract：Osteoporosis fractures,also known as fragility fractures,continue to pose a significant global health and economic challenge.Current fracture prediction methods primarily rely on bone mineral density measurement,trabecu-lar bone score(TBS),and the utilization of mathematical risk calculators like the Fracture Risk Assessment Tool(FRAX),based on clinical risk factors for bone fragility.Despite these approaches,a considerable number of bone frac-tures remain undetected in the early stages.Consequently,ongoing research is dedicated to identifying new factors,such as bone turnover markers(BTMs),to enhance risk assessment.The determination of BTMs holds crucial clinical value in diagnosing and differentiating various skeletal diseases,monitoring osteoporosis progression,stratifying fragility fracture risks,evaluating drug treatment responses,and ensuring adherence.However,the potential application of BTMs in moni-toring bone turnover and fracture risk is constrained by physiological and pathophysiological factors affecting BTMs.This limitation,in turn,restricts their inclusion in clinical guidelines.
Keywords：osteoporosisbone turnover markersfragility fracture
Publication Date：2024-01-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 6-11 )