Preliminary analysis of clinical conditions,coagulation and inflammatory markers in patients with long CO VID-19

LI Hui; CAI Dong-hao; WANG Nan; CHEN Li-dan

doi:10.13820/j.cnki.gdyx.20233132

Abstract：Objective To analyze the distribution characteristics of clinical conditions and the changes in biomar-kers of coagulation and inflammation in patients with Long CO VID-19(LC)and preliminarily explore the risk factors and possible mechanism of LC.Methods A total of 44 patients with persistent symptoms 30 days after infection with light or moderate COVID-19 were collected.The clinical symptoms of the included patients were descriptively analyzed,and the occurrence rate of the symptoms was counted.The biological markers of coagulation and inflammation in LC patients were evaluated,and the mean and standard deviation of each index were calculated to observe the normal and abnormal inci-dence.Results Of the 44 LC patients,there were 14 males(31.82％)and 30 females(68.18％),showing that the female patients were significantly more than the male patients.The age of onset was concentrated in 41-60 years old.15.90％of the included patients had diabetes.The main symptoms of LC patients were chest tightness(36.36％),in-somnia(22.73％),palpitations(18.18％),cough(13.64％),chest pain(9.09％),and fatigue(9.09％).Pro-thrombin time(PT)and activated partial thromboplastin time(APTT)were shortened,fibrinogen(FIB)and platelet(PLT)were increased in only 5％-10％of patients with LC,and D-Dimer was increased in 20％of patients with LC.More than 90％of patients with LC had normal inflammatory indicators.Conclusion Middle-aged,female and diabetic patients may be the risk factors for LC patients.The clinical symptoms that persist in patients with LC are mainly from the circulatory,respiratory and nervous systems.Cytokine storm,endothelial damage,and widespread microthrombus during COVID-19 return to normal during LC,making them no longer the main pathogenic mechanism of LC.The causes of the persistence of LC symptoms requires further study.