Application of MRI enhanced scanning combined with serum CRNDE and NRSN2 in the staging diagnosis and ef-ficacy evaluation of nasopharyngeal carcinoma

ZHENG Shu-cheng; ZHANG De-jiang; CHEN Di; WANG Long; LI Yu-zhu

doi:10.13820/j.cnki.gdyx.20232043

Abstract：Objective To analyze the application of MRI enhanced scanning combined with serum differential ex-pression genes(CRNDE)and neurensin-2(NRSN2)in staging diagnosis and efficacy evaluation of nasopharyngeal car-cinoma.Methods A total of 110 patients diagnosed with nasopharyngeal carcinoma were selected as the study subjects.According to the staging,they were divided into the early-stage group(46 cases,Stage Ⅱ)and the middle-to-late-stage group(64 cases,Stage Ⅲ and Ⅳ).All patients underwent MRI enhanced scanning and radiochemotherapy.Based on the efficacy of radiochemotherapy,patients were categorized into the good efficacy group and poor efficacy group.Pear-son's method was used to analyze the correlation between serum CRNDE,NRSN2,and their correlation with MRI en-hanced scanning parameters.Receiver operating characteristic(ROC)curve analysis was performed to evaluate the diag-nostic value of combined MRI enhanced scanning parameters with serum CRNDE and NRSN2 levels in staging nasopharyn-geal carcinoma.Results The maximum upslope,time to peak,CRNDE,and NRSN2 levels in the middle-to-late-stage group were significantly higher than those in the early-stage group(P＜0.05).Pearson correlation analysis re-vealed a positive correlation between serum CRNDE and NRSN2 levels(P＜0.05),and both were positively correlated with the maximum upslope and time to peak(P＜0.05).According to the ROC curve,the area under the curve(AUC)for diagnosing nasopharyngeal carcinoma staging was 0.798 for the maximum upslope,0.854 for time to peak,and 0.918 for the combination of both,which was superior to individual diagnosis(Zcombined vs.maximum upslope=2.628,Zcombined vs.time to peak=2.731,P＜0.05).The AUC for CRNDE,NRSN2,and MRI enhanced scanning alone in diagnosing nasopharyngeal car-cinoma staging was 0.841,0.864,and 0.918,respectively.The AUC for the combination of all three was 0.984,which was superior to individual diagnosis(Zcombined vs.CRNDE=2.510,Zcombined vs.NRSN2=2.685,Zcombined vs.MRI enhaneed scanning=2.821,P＜0.05).The levels of maximum upslope,time to peak,CRNDE,and NRSN2 in the poor efficacy group were significantly higher than those in the good efficacy group(P＜0.05).Conclusion MRI enhanced scanning combined with serum CRNDE and NRSN2 has high clinical value in the staging diagnosis of nasopharyngeal carcinoma,and it is closely related to the efficacy of radiochemotherapy in patients.