Correlation analysis of serum sLOX-1,hs-CRP levels,and CHA2 DS2-VASc score with no-reflow phenom-enon after acute myocardial infarction surgery
CHEN Hong-wei
CAO Jun
ZHANG Ji-wei
REN Jun-yan
HOU Zi-min
Abstract：Objective To investigate the correlations between serum soluble lectin-like oxidized low-density lipoprotein receptor-1(sLOX-1),high-sensitivity C-reactive protein(hs-CRP)levels,CHA2 DS2-VASc score,and the occurrence of no-reflow phenomenon after percutaneous coronary intervention(PCI)in patients with acute myo-cardial infarction(AMI).Methods A total of 500 AMI patients from July 2021 to March 2023 were selected.Accord-ing to the postoperative thrombolysis in myocardial infarction(TIMI)grading,the 500 patients were divided into no-re-flow group(n=92)and reflow group(n=408).Clinical data were collected,and serum sLOX-1 levels were measured using enzyme-linked immunosorbent assay(ELISA),while hs-CRP levels were measured using immunoturbidimetric assay.Clinical data,serum sLOX-1 and hs-CRP levels,and CHA2 DS2-VASc scores were compared between the two groups.Multifactor logistic regression analysis was used to analyze the influencing factors of no-reflow after PCI in AMI patients.Receiver operating characteristic(ROC)curve analysis performed to evaluate the predictive value of serum sLOX-1,hs-CRP levels,and CHA2 DS2-VASc score for no-reflow phenomenon after PCI in AMI patients.Results Univariate analysis indicated that the length of the lesion vessel,time from onset to vessel recanalization,TIMI grading at admission,history of diabetes,and history of heart failure were significantly correlated to no-reflow after PCI(P＜0.05).Compared with the reflow group,the no-reflow group had significantly higher serum sLOX-1 levels,hs-CRP levels,and CHA2 DS2-VASc scores(P＜0.05).Multivariate logistic regression analysis revealed that sLOX-1,hs-CRP,CHA2 DS2-VASc score,lesion vessel length,preoperative TIMI flow grading,history of heart failure,and history of diabetes were independent risk factors for no-reflow phenomenon after PCI in AMI patients(P＜0.05).ROC curve a-nalysis showed that the individual area under ROC curve(AUC)of serum sLOX-1,hs-CRP,and CHA2 DS2-VASc score in predicting no-reflow phenomenon after PCI in AMI patients were 0.817(95％CI:0.780-0.850),0.840(95％CI:0.805-0.871),and 0.821(95％CI:0.785-0.854),respectively.When combined,the AUC was 0.925(95％CI:0.898-0.946),which was significantly larger than the AUC of serum sLOX-1 alone(Z=4.408,P=0.000),hs-CRP alone(Z=3.742,P=0.000),and CHA2 DS2-VASc score alone(Z=3.952,P=0.000).Conclusion Serum sLOX-1,hs-CRP levels,and CHA2 DS2-VASc score are associated with the occurrence of no-reflow phenomenon after PCI in AMI patients,and their combination has a high predictive value for no-reflow phenome-non after PCI.
Keywords：acute myocardial infarctionsoluble lectin-like oxidized low density lipoprotein receptor-1high-sensitivity C-reactive protein
Publication Date：2023-12-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 1542-1547 )