Associations between APN gene-11426a/G polymorphism and serum APN level with risk of GDM and the deliv-ery outcome

ZHANG Jing; WANG Shuai; GUO Xiu-xiu; BAI Ying; LI Fang

doi:10.13820/j.cnki.gdyx.20224389

Abstract：Objective To investigate the associations between APN gene-1426a/G polymorphism and serum APN level with the risk of GDM and delivery outcome.Methods In this study,a prospective study was conducted in 80 patients with gestational diabetes mellitus(GDM)who were diagnosed and treated in our hospital from June 2019 to June-2021.At the same time,80 cases of gestational impaired glucose tolerance(GIGT)and normal glucose tolerance nor-mal group(NGT)in our hospital during the same period were randomly selected as the control group.To compare the differences of APN gene-11426a/G polymorphism and serum APN level among the three groups,and to study the correla-tion between APN gene-11426a/G polymorphism and serum APN level and the risk of GDM and delivery outcome.Results The prevalence of GG,AG,AA,G and A were 15.79％,18.89％,58.06％,17.16％and 45.29％,respec-tively,in GDM group;and 28.07％,36.67％,33.33％,31.86％and 34.42％,respectively,in GIGT group.And they were 56.14％,44.44％,8.60％,50.98％and 20.29％,respectively,in NGT group.There were significant differences in-11426A/G genotype,allele and serum APN among GDM group,GIGT group and NGT group(P＜0.05).The minimum allele frequencies for all genes in the study were consistent with the Hardy-Weinberg equilibrium.The differences in AA and AG alleles of-11426A/G gene between the two groups were statistically significant(P＜0.05).The differences in-11426A/G genotypes,alleles and serum APN levels between normal and adverse pregnancy outcomes were statistically significant(P＜0.05).There was a significant correlation between the risk of GDM and differ-ent pregnancy outcomes and-11426A/G polymorphism.Conclusion There is a significant correlation between APN gene-11426A/G polymorphism,serum APN level,and the risk of GDM and delivery outcomes.