Effect of baseline age on long-term immune function of HIV antiviral therapy

HE Song-hua; MO Bing-dong; LUO Ke-yu; QIN Xiang-song; ZHANG Peng; JIANG Zhong-sheng

doi:10.13820/j.cnki.gdyx.20232049

Abstract：Objective To investigate the effects of antiretroviral therapy(ART)on long-term immune function in baseline age patients with HIV infection or AIDS.Methods A total of 1 832 newly treated patients who were followed up in the care outpatient department of Liuzhou People's Hospital from January 2004 to December 2021 were collected,in-cluding 1 292 males and 540 females.Patients were categorized into three groups based on baseline age:Group 1(age＜35 years,557 patients),Group 2(age 35-50 years,675 patients),and Group 3(age＞50 years,600 patients).Fol-low-up visits were conducted every three months.The generalized estimating equation(GEE)was used to compare the changes in peripheral blood CD4+T lymphocyte counts after initiating ART(0-120 months)among the three age groups.Results The GEE parameter estimates indicated that there were statistically significant differences in CD4+T lymphocyte count changes among the age groups during the first 66 months of follow-up after initiating ART(P＜0.05).However,after 66 months of follow-up,there were no statistically significant differences in CD4+T lymphocyte count changes among the age groups(P＞0.05).Conclusion Most HIV/AIDS patients experience a certain degree of immune function recovery with extended treatment duration.However,special attention should be given to patients over 50 years of age.