Study of secretory phospholipase A2 level in children with bronchiolitis and asthma and its effect on the curative efficacy of leukotriene receptor antagonist
GUO Qing
SHEN Zhao-bo
SUN Xiao-min
CHEN Dan
KANG Ping
Abstract：Objective To discuss the significance of secretory phospholipase A2 (sPLA2) in children with bronchiolitis and asthma and its effect on the curative efficacy of leukotriene receptor antagonist. Methods Eighty children with bronchiolitis, 80 children with asthma and 40 health controls were selected. The patients were treated with leukotriene receptor antagonist. The sPlA2, leukotriene C4 (LTC4), interleukin-4 (IL-4), interferon-γ (IFN-γ) and immunoglobulin E (IgE) in peripheral blood and urinary leukotriene E4 (LTE4) were measured and compared before and after treatment. The correlations of sPLA2 with other indexes were analyzed and the curative effect were compared. Results The sPLA2 in bronchiolitis group and asthma group were significantly higher than controls (P＜0.05). The sPLA2 was significantly correlated with the leukotriene indexes and inflammation indexes (P＜0.05). In bronchiolitis group, the curative efficacies among different sPLA2 level groups were significantly different (χ2=7.683, P=0.021). The clinical crisis, fever disappeared time, cough disappeared time and recurrence ratio in high sPLA2 group were significantly higher than low sPLA2 group (P＜0.05). In asthma group, there was no significant difference in curative efficacies among different sPLA2 level groups (χ2=3.360, P=0.186), but the fractional exhaled nitric oxide in high sPLA2 group were significantly higher than low-sPLA2 group (P＜0.05). In the both groups, the index improvement in low sPLA2 group were significantly better than high sPLA2 group (P＜0.05). Conclusion The level of sPLA2 is correlated with the state and curative effect of leukotriene receptor antagonist for bronchiolitis children; is correlated with the airway inflammation but not with the curative efficacy for asthma.
Keywords：secretory phospholipase A2leukotrienesbronchiolitisasthmainflammatory
Publication Date：2019-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 665-670 )