Regional-homogeneity-based analysis on first-episode schizophrenia patients: a resting-state fMRI study
LI Ri-peng
LU Xiao-bing
ZOU Wen-jin
HUANG Xiong
Abstract：Objective To analysis the brain function in the first-episode schizophrenia patients by using regional-homogeneity (ReHo), and investigate the brain regions with abnormal functioning in resting state. Methods A total of 20 first-episode schizophrenia patients and 20 matched healthy controls were recruited. All participants received functional magnetic resonance imaging scans. And the patients were assessed using the positive and negative symptom scale. The ReHo was applied in the SPM8 software package to analyze the changes of brain function. The ReHo in the patients and its association with psychiatric symptoms were analyzed. Results Compared with the controls, the patients showed significantly reduced ReHo in the left inferior temporal gyrus, with significantly increased ReHo in the right anterior cerebellar and the right superior parietal lobule (P＜0.05). Conclusion There are some abnormal ReHo at certain brain regions in the early stages of schizophrenia, suggesting that may be the existence of abnormal brain function in the resting state.
Keywords：first-episode schizophreniaresting-state fMRIregional-homogeneity
Publication Date：2019-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 661-664 )