The correlation between serum insulin-like growth factor-1 and diabetes mellitus complicated with thyroid diseases

YAN Yuan-yuan; WEI Jian-fen; LI Shi-chao; WANG Bao-zhuo

doi:10.3969/j.issn.1001-9448.2019.05.008

Abstract：Objective To investigate the role of serum insulin-like growth factor-1 (IGF-1) in the pathogenesis of diabetes mellitus complicated with thyroid disease by analyzing the difference of serum IGF-1 among patients with diabetes mellitus and different thyroid diseases; thus to provide theoretical basis for the prevention and treatment of thyroid diseases in diabetes patients. Methods A total of 190 patients with type 2 diabetes mellitus (T2 DM) in the hospital of North China University of Technology from August 2017 to May 2018 were selected and divide into diabetes mellitus combined with thyroid disease groups and simple diabetes mellitus group according to whether they were combined with thyroid disease or not. The serum IGF-1, thyroid function, insulin, C peptide, blood glucose, glycosylated hemoglobin, insulin resistance index and blood lipid among each groups were compared. Results The serum IGF-1 in patients with diabetes mellitus combined with hyperthyroidism and with diabetes mellitus combined with hypothyroidism group were significantly lower than those in patients with diabetes mellitus with thyroid nodules and simple diabetes mellitus (P＜0.05). IGF-1 was significantly negatively correlated with age, course of diabetes mellitus, BMI, T3, T4, FT3, FT4, TGAb and HDL (R values were-0.307, -0.317, -0.817, -0.204, -0.274, -0.287, -0.208, respectively, P＜0.05), as IGF-1 was significantly positively correlated with FPG, 2 hPPG, Fins and IR (R values were 0.891, 0.174, 0.661 and 0.660, respectively, P＜0.05). According to logistic regression, serum IGF-1 was significantly negatively correlated with diabetes mellitus combined thyroid disease.Conclusion The serum IGF-1 is associated with diabetes mellitus complicated with thyroid diseases, and may play an important role in the occurrence and development of the disease. It also provides a theoretical basis for the prevention of thyroid disease in diabetic patients. And it can be used as an index to evaluate the clinical intervention efficacy.