Effects of general anesthesia combined with combined spinal-epidural anesthesia on the postoperative wake-up time and changes of serum levels of immunoglobulin and C3 in laparoscopic surgery for patients with low rectal cancer
cancer.ZHAO Li
PENG Jing
ZHOU Min
WANG Zhong-hui
Abstract：Objective To investigate the effect of general anesthesia combined with combined spinal-epidural anesthesia on the postoperative wake-up time and changes of serum levels of immunoglobulin and complement 3 (C3) in laparoscopic surgery for patients with low rectal cancer. Methods 78 patients with low rectal cancer treated by laparoscopic surgery were divided into the control group and the observation group according to the drawing method. The participants in observation group received general anesthesia combined with combined spinal-epidural anesthesia, as those in control group received general anesthesia. The hemodynamic indexes, including mean arterial pressure (MAP) and heart rate (HR), before anesthesia, after induction of anesthesia, at the time of establishment of pneumoperitoneum, and after operation were recorded; and serum levels of immunoglobulin (IgM, IgG) and C3 before anesthesia, after pneumoperitoneum establishment, and 24 h and 72 h after operation were compared. The time of recovery of respiration, the time of awakening, the time of extubation and the occurrence of adverse reactions were compared between the two groups.Results There was no significant difference in the levels of MAP and HR between the two groups before anesthesia (P＞0.05). The levels of MAP and HR in the observation group were significantly lower than those of the control group after the establishment of the pneumoperitoneum (P＜0.05). There was no significant differences in serum level of IgM, IgG or C3 between the two groups before anesthesia (P＞0.05). The levels of serum IgM, IgG and C3 24 h and 72 h after operation and after the establishment of the pneumoperitoneum of the observation group were significantly higher than those of the control group (P＜0.05). The time of recovery of respiration, the time of awakening and the time of extubation of the observation group were significantly shorter than those of the control group (P＜0.05). There was no significant difference in the incidence of adverse reactions between the 2 groups (P＞0.05). Conclusion General anesthesia combined with combined spinal-epidural anesthesia in laparoscopic surgery for patients with low rectal cancer can significantly shorten the postoperative time of recovery of respiration, the time of awakening and the time of extubation; promote postoperative anesthesia recovery; and stabilize the hemodynamic state. It has little influence on immune function and is safe.
Keywords：low rectal cancerlaparoscopic surgerygeneral anesthesiacombined spinal and epidural anesthesiapostoperative recovery timeimmunoglobulincomplement 3
Publication Date：2019-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 526-530 )