Analysis of the correlation of Aiolos gene polymorphism with systemic lupus erythematosus in Guizhou Han population
YANG Ying
CHEN Xiao-hong
CHEN Lin
LIANG Han-yue
LUO Li
JIA Chang-sha
CHEN Yong-yan
YAN Wen
Abstract：Objective To investigate the correlations of the polymorphism of Aiolos gene rs9909593, rs9635726 and rs12150079 with systemic lupus erythematosus (SLE) in Guizhou Han population. Methods The case-control study was conducted on 213 SLE patients and 187 healthy controls. The 3 SNPs (rs9909593, rs9635726 and rs12150079) of Aiolos gene was analyzed by snapshot technology. The susceptibility between gene and SLE was analyzed through the non-conditional logistic-regression model. Results The frequencies of genotype AG, GG and AA in SLE group were 0.437％, 0.080％ and 0.483％, respectively; and in control group were 0.412％, 0.064％ and 0.524％, respectively. The frequencies of allele A and G of Aiolos rs9909593 were 0.702％ and 0.298％, respectively, in SLE group; and 0.730％ and 0.270％, respectively, in control group. There was no significant difference in genotype frequency or allele frequency of Aiolos rs9909593 between the two groups (P＞0.05). The frequencies of genotype CT, CC and TT in SLE group were 0.437％, 0.094％ and 0.469％, respectively; and in control group were 0.422％, 0.064％ and 0.513％, respectively. The frequencies of C and T in SLE group were 0.312％ and 0.688％, respectively;and in control group were 0.275％ and 0.725 ％, respectively. There was no significant difference in genotype frequency and allele frequency of Aiolos rs9635726 between the two groups (P＞0.05). The frequencies of genotype AG, GG and AA of Aiolos rs12150079 in SLE group were 0.310％, 0.042％ and 0.648％, respectively; and in control group were 0.326％, 0.032％ and 0.642％, respectively. The frequencies of allele A and G of Aiolos rs12150079 in SLE group were 0.197％ and 0.803％, respectively; and in control group were 0.195％ and 0.805％, respectively. There was no significant difference in genotype frequency or allele frequency of Aiolos rs12150079 between the two groups (P＞0.05). Logistic regression model analysis suggested that rs9909593, rs9635726 and rs12150079 had no significant correlation with SLE in the additive model, dominant model and implicit model (P＞0.05). The rs12150079 were completely unbalant with rs9635726 and rs9909593 (D′≥1, r2≥0.584). The rs9635726 and rs9909593 had strong linkage disequilibrium (D′=0.877, r2=0.733). Joint genotype analysis found that there was no significant difference in the distribution of 5 single haplotype (ACG, GCA, GCG, GTA, GTG) between SLE group and control group (P＞0.05). The non-conditional logistic-regression model analysis showed that the haplotype had nothing to do with the incidence of SLE. Conclusion The single nucleotide polymorphism of Aiolos gene rs9909593, rs9635726 and rs12150079 is not associated with the risk of SLE in Guizhou Han population.
Keywords：Aiolos geneSLEsingle nucleotide polymorphismgenotype frequencyallele frequencylinkage disequilibriumhaplotype
Publication Date：2019-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 519-525 )