Comparative study on the molecular characteristics of Mycobacterium tuberculosis in rural and urban areas of Jiangxi province
XIONG Guang-chu
CHEN Qiang
ZHANG Qi
LUO Dong
LIU Tao
PENG Yi-ping
CHEN Kai-sen
Abstract：Objective To investigate the molecular characteristics of drug-resistant M tuberculosis in rural and urban population of Jiangxi Province, thus to provide more targeted prevention and treatment of TB. Methods The M. tuberculosis were isolated. Drug-resistance was tested with absolute concentration method. Multiple-PCR was applied to detect Beijing family strains or not. The 15 loci MIRU-VNTRs method was applied to genotype the strains. The allelic difference, resolution, clustering rate and recent infection rate were calculated.Results A total of 371 M. tuberculosis were collected, from 294 rural patients and 77 urban patients. The molecular characterization of these patients in country and urban had no significant difference in strains, among which was Beijing genotype the major clone. HGDI was 0.996 9 in rural patients, and 0.993 5 in urban patients. There were 33 clusters found from 371 strains, with the cluster rate of 28.64％. The tuberculosis transmitted rate in urban was 15.58％ and 18.03％ in rural. Conclusion There is no distinct difference in molecular characterization between the rural and urban drug-resistant tuberculosis in Jiangxi province.
Keywords：drug-resistant M.tuberculosisgenotypingrural patientsurban patients
Publication Date：2019-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 503-506 )